Pat fish dry and season on both sides with salt and pepper.
Place flour, egg, and panko in three shallow bowls. Add Old Bay to panko and toss to combine. Working one at a time, coat fish in flour, then in egg, and finally in panko, pressing to coat.
Working in batches, place fish in basket of air fryer and cook at 400° for 10 to 12 minutes, gently flipping halfway through, or until fish is golden and flakes easily with a fork.